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Signaling pathway crosstalk
during epithelial homeostasis and pathogenesis
How do cells coordinate prolifeartion, differentiation and morphogenetic movements in time and space to build functional tissues? They receive input from a multitude of different signaling pathways that regulate these processes. Ongoing projects in the laboratory aim to unravel how pathway cross-talk shapes cellular output during homeostasis and disease.
CELL INTERCALATION
CELL INTERCALATION
How do signaling pathways coordinate cellular behavior to allow healthy morphogenetic processes?
Using live imaging we investigate how signaling pathways control mechanical properties of tissues to govern coordinated migration. View our latest publication and preprint.
SIGNALING CROSSTALK
SIGNALING CROSSTALK
How do signaling pathways interact to establish cell type-specific transcriptional landscapes?
We combine scRNA-seq with cell biological and genetic tools to understand how complex tissues are build. View our latest publication here.
CANCER CACHEXIA
CANCER CACHEXIA
How does signaling pathway deregulation in epithelia trigger systemic effects?
We apply metabolomics and proteomic approaches to connect cellular output of signaling deregulation to systemic effects. This project is funded by the von Behring Röntgen Stiftung.
Find us on Bluesky: @rustflylab.bsky.social
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